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KMID : 0644320000060010029
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Journal of Korean Oriental Oncology
2000 Volume.6 No. 1 p.29 ~ p.45
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Antitumor and Immunomodulatory Effects of Dangguihwalhyultang on Murine Melanoma-induced Lung Metastasis
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고은태/Ko, Eun Tae
하지용/이선구/유병길/Ha, Jee Yong/Lee, Seon Goo/You, Byeong Gil
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Abstract
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In order to investigate the antitumor effect by Dangguihwalhyultang after B-l6 cells were transplanted in C57BL/6 mice, and the immune responses in mice induced by methotrexate, the extract of Dangguihwalhyultang was orally administered to the ICR mice.
Experimental studies were performed for measurance of metastasis, cell cytotoxicity in vitro, life
extention, weight of cancer, natural killer cell activity. productivity of interleukin-2.
The results were summarized as follows:
l. Mean survival time in Dmgguihwalhyultang-treated group was prolonged. as compared with control group(14.63%) significantly(P<0.05).
2. Inhibition of metastasis in Dangguihwalhyultang-treated group was higher than control goroup with significance on 14th day(P<0.05).
3. On the weight of solid tumor. Dangguihwalhyultang-treated group was less than control group with significance(P<0.05).
4. On the MTT assay. Dangguihwalhyultang concernration inhibited cell viability was 368.8ug/well.
5. Natural killer cell activity in Dangguihwalhyultang-treated group was significantly increased on100:1, 50:l E/T(effect cell/target cell) ratio(P< 0.05).
6. Production of interleukin-2 in Dangguihwalhyultang-treated group was significantly inoesd(P<0.05).
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